PYY - Y 1 R signaling increases food intake 7 8
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چکیده
1 2 3 Peptide YY signaling in the lateral parabrachial nucleus increases food intake 4 through the Y1 receptor 5 6 Running Title: lPBN PYY-Y1R signaling increases food intake 7 8 Amber L. Alhadeff1, Danielle Golub1, Matthew R. Hayes2, Harvey J. Grill1 9 1Department of Psychology, 2Department of Psychiatry 10 University of Pennsylvania, Philadelphia, PA 19104 11 12 13 14 15 16 17 18 Corresponding Author: 19 Amber L. Alhadeff 20 3720 Walnut Street 21 Philadelphia, PA 19104 22 [email protected] 23 24 25
منابع مشابه
Peptide YY signaling in the lateral parabrachial nucleus increases food intake through the Y1 receptor.
Although central PYY delivery potently increases food intake, the sites of action and mechanisms mediating these hyperphagic effects are not fully understood. The present studies investigate the contribution of lateral parabrachial nucleus (lPBN) PYY-Y receptor signaling to food intake control, as lPBN neurons express Y receptors and receive PYY fibers and are known to integrate circulating and...
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PEPTIDE YY (PYY) is a 36-amino acid peptide belonging to the pancreatic polypeptide (PP)-fold family of peptides that also includes PP and neuropeptide Y. PYY is colocalized with GLP-1 in L-type endocrine cells of the distal intestinal mucosa and is released in response to intraluminal nutrient stimulation with peak levels occurring 1 to 2 h postingestion (1, 2). After its release, PYY is cleav...
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